Lyons is a borough that is located in Berks County, Pennsylvania, United States. The population was 439 at the time of the 2020 census.

The Late-May 1998 tornado outbreak and derecho was a historic tornado outbreak and derecho that began on the afternoon of May 30 and extended throughout May 31, 1998, across a large portion of the northern half of the United States and southern Ontario from southeastern Montana east and southeastward to the Atlantic Ocean. The initial tornado outbreak, including the devastating Spencer tornado, hit southeast South Dakota on the evening of May 30. The Spencer tornado was the most destructive and the second-deadliest tornado in South Dakota history. A total of 13 people were killed; 7 by tornadoes and 6 by the derecho. Over two million people lost electrical power, some for up to 10 days.