M-106 is a state trunkline highway in the Lower Peninsula of the US state of Michigan in and near the city of Jackson. M-106 travels in a southwest-to-northeast direction from Jackson to Gregory at a junction with M-36 just a few miles northwest of Hell. The highway was first designated in 1928 running north out of downtown Jackson. It connected U.S. Highway 12 (US 12) to the state prison and Bunkerhill Road. A pair of changes in the early 1930s resulted in the extension eastward to Gregory. From the 1960s until the early years of the 21st century, a section of M-106 in downtown Jackson was routed along one-way streets.

Jackson is the only city in, and seat of government of, Jackson County in the U.S. state of Michigan. As of the 2020 census, the city population was 31,309. Located along Interstate 94 and U.S. Route 127, it is approximately 40 miles (64 km) west of Ann Arbor and 35 miles (56 km) south of Lansing. Jackson is the core city of the Jackson Metropolitan Statistical Area, which includes all of Jackson County and has a population of 160,248.