M-106 is a state trunkline highway in the Lower Peninsula of the US state of Michigan in and near the city of Jackson. M-106 travels in a southwest-to-northeast direction from Jackson to Gregory at a junction with M-36 just a few miles northwest of Hell. The highway was first designated in 1928 running north out of downtown Jackson. It connected U.S. Highway 12 (US 12) to the state prison and Bunkerhill Road. A pair of changes in the early 1930s resulted in the extension eastward to Gregory. From the 1960s until the early years of the 21st century, a section of M-106 in downtown Jackson was routed along one-way streets.

M-52 is a north–south state trunkline highway in the US state of Michigan. The southern terminus is on the Ohio border, where it continues as State Route 109. The highway passes through communities like Adrian, where it intersects US Highway 223 (US 223), Chelsea and Webberville along its 127.3-mile-long (204.9 km) course. It crosses some major rivers, including the River Raisin and the Shiawassee. The section of the highway between M-50 and Manchester was built as a limited-access highway. M-52's northern terminus is at M-46, nine miles (14 km) west of Saginaw.