M-28 is an east–west state trunkline highway that traverses nearly all of the Upper Peninsula of the U.S. state of Michigan, from Wakefield to near Sault Ste. Marie in Bruce Township. Along with US Highway 2 (US 2), M-28 forms a pair of primary highways linking the Upper Peninsula from end to end, providing a major access route for traffic from Michigan and Canada along the southern shore of Lake Superior. M-28 is the longest state trunkline in Michigan numbered with the "M-" prefix at 290.373 miles (467.310 km). The entire highway is listed on the National Highway System, while three sections of M-28 are part of the Lake Superior Circle Tour. M-28 also carries two memorial highway designations along its route.

US Highway 2 (US 2) is a component of the United States Numbered Highway System that connects Everett, Washington, to the Upper Peninsula (UP) of the US state of Michigan, with a separate segment that runs from Rouses Point, New York, to Houlton, Maine. In Michigan, the highway runs through the UP in two segments as a part of the state trunkline highway system, entering the state at Ironwood and ending at St. Ignace; in between, US 2 briefly traverses the state of Wisconsin. As one of the major transportation arteries in the UP, US 2 is a major conduit for traffic through the state and neighboring northern Midwest states. Two sections of the roadway are included as part of the Great Lakes Circle Tours, and other segments are listed as state-designated Pure Michigan Byways. There are several memorial highway designations and historic bridges along US 2 that date to the 1910s and 1920s. The highway runs through rural sections of the UP, passing through two national and two state forests in the process.