M-46 is an east–west state trunkline highway in the US state of Michigan between Muskegon and Port Sanilac, terminating near Lake Michigan and Lake Huron on each end. Except for the north–south segment that corresponds with the US Highway 131 (US 131) freeway between Cedar Springs and Howard City, M-46 is practically a due east–west surface highway. The road runs through rural sections of the Lower Peninsula connecting several freeways including US 31, US 131, US 127 and Interstate 75 (I-75).

Sanilac County is a county located in the Thumb region of the U.S. state of Michigan. As of the 2020 Census, the population was 40,611. The county seat is Sandusky. The county was created on September 10, 1822, and was fully organized on December 31, 1849. Sanilac County is considered to be part of the Thumb of Michigan, a subregion of the Flint/Tri-Cities. Sanilac County enjoys seasonal tourism in towns such as Lexington, Port Sanilac, and Carsonville. Sanilac County is economically attached to St. Clair County and Huron County and is largely composed of nearly flat areas of rich soil.