M-50 is a state trunkline highway in the US state of Michigan. Although designated as an east–west highway, it is nearly a diagonal northwest–southeast route. The western terminus is at exit 52 along Interstate 96 (I-96) near Alto a few miles east of the metro Grand Rapids area, and its eastern terminus is in downtown Monroe at US Highway 24. In between the trunkline runs through seven counties of the southern part of the Lower Peninsula mostly through rural farm fields and small communities. The highway also runs through downtown Jackson to connect between two freeway sections of US 127. In the Irish Hills area of the state southeast of Jackson, M-50 runs next to Michigan International Speedway.

Interstate 96 (I-96) is an east–west Interstate Highway that runs for approximately 192 miles (309 km) entirely within the Lower Peninsula of the US state of Michigan. The western terminus is at an interchange with US Highway 31 (US 31) and Business US 31 on the eastern boundary of Norton Shores southeast of Muskegon, and the eastern terminus is at I-75 near the Ambassador Bridge in Detroit. From Grand Rapids through Lansing to Detroit, the freeway parallels Grand River Avenue, never straying more than a few miles from the decommissioned US 16. The Wayne County section of I-96 is named the Jeffries Freeway from its eastern terminus to the junction with I-275 and M-14. Though maps still refer to the freeway as the Jeffries, the portion within the city of Detroit was renamed by the state legislature as the Rosa Parks Memorial Highway in December 2005 in honor of the late civil rights pioneer. There are four auxiliary Interstates as well as two current and four former business routes associated with I-96.