M-53 is a north–south state trunkline highway in the US state of Michigan that connects Detroit to The Thumb region. The highway starts in Detroit at a connection with M-3 and ends in Port Austin, Michigan at M-25. In between, the trunkline passes through the northern suburbs of Metro Detroit, connects to freeways like Interstate 69 (I-69) and provides access to rural farmland. In Macomb County, M-53 follows the Christopher Columbus Freeway and POW/MIA Memorial Freeway, while the remainder of the highway is known as Van Dyke Avenue in the metro area or Van Dyke Road elsewhere. The highway has also been named the Earle Memorial Highway for one of the pioneers of the Good Roads Movement and Michigan's highway system.

The State Trunkline Highway System consists of all the state highways in Michigan, including those designated as Interstate, United States Numbered, or State Trunkline highways. In their abbreviated format, these classifications are applied to highway numbers with an I-, US, or M- prefix, respectively. The system is maintained by the Michigan Department of Transportation (MDOT) and comprises 9,669 miles (15,561 km) of trunklines in all 83 counties of the state on both the Upper and Lower peninsulas, which are linked by the Mackinac Bridge. Components of the system range in scale from 10-lane urban freeways with local-express lanes to two-lane rural undivided highways to a non-motorized highway on Mackinac Island where cars are forbidden. The longest highway is nearly 400 miles (640 km) long, while the shortest is about three-quarters of a mile. Some roads are unsigned highways, lacking signage to indicate their maintenance by MDOT; these may be remnants of highways that are still under state control whose designations were decommissioned or roadway segments left over from realignment projects.