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MDMA

3,4-Methyl​enedioxy​methamphetamine known as ecstasy or molly, is a psychoactive drug used as a recreational drug. The desired effects include altered sensations, increased energy and pleasure; when taken by mouth, effects begin in last 3 to 6 hours. Adverse effects include addiction, memory problems, difficulty sleeping, teeth grinding, blurred vision, a rapid heartbeat. Deaths have been reported due to dehydration. Following use people feel depressed and tired. MDMA acts by increasing the activity of the neurotransmitters serotonin and noradrenaline in parts of the brain, it belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects. MDMA is illegal in most countries and, has no approved medical uses. Limited exceptions are sometimes made for research. Researchers are investigating whether MDMA may assist in treating severe, treatment-resistant posttraumatic stress disorder with phase 3 clinical trials to look at effectiveness and safety expected to begin in 2018.

In 2017, the FDA granted MDMA a breakthrough therapy designation for PTSD, meaning that if studies show promise, a review for potential medical use could occur more quickly. MDMA was first developed in 1912 by Merck, it was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is associated with dance parties and electronic dance music, it may be mixed with other substances such as ephedrine and methamphetamine. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy; this was broadly similar to the percentage of people who use cocaine or amphetamines, but lower than for cannabis or opioids. In the United States, as of 2017, about 7% of people have used MDMA at some point in their lives and 0.9% have used it in the last year. In general, MDMA users report feeling the onset of subjective effects within 30 to 60 minutes of oral consumption and reaching peak effect at 75 to 120 minutes, which plateaus for about 3.5 hours. The desired short-term psychoactive effects of MDMA have been reported to include: Euphoria – a sense of general well-being and happiness Increased self-confidence and perception of facilitated communication Entactogenic effects—increased empathy or feelings of closeness with others and oneself Dilated pupils Relaxation and reduced anxiety Increased emotionality A sense of inner peace Mild hallucination Enhanced sensation, perception, or sexuality Altered sense of timeThe experience elicited by MDMA depends on the dose and user.

The variability of the induced altered state is lower compared to other psychedelics. For example, MDMA used at parties is associated with high motor activity, reduced sense of identity, poor awareness of surroundings. Use of MDMA individually or in small groups in a quiet environment and when concentrating, is associated with increased lucidity, sensitivity to aesthetic aspects of the environment, enhanced awareness of emotions, improved capability of communication. In psychotherapeutic settings, MDMA effects have been characterized by infantile ideas, mood lability, memories and moods connected with childhood experiences. MDMA has been described as an "empathogenic" drug because of its empathy-producing effects. Results of several studies show the effects of increased empathy with others; when testing MDMA for medium and high doses, it showed increased arousal continuum. The effect of MDMA increasing sociability is consistent, while its effects on empathy have been more mixed. MDMA is considered the drug of choice within the rave culture and is used at clubs and house parties.

In the rave environment, the sensory effects of music and lighting are highly synergistic with the drug. The psychedelic amphetamine quality of MDMA offers multiple appealing aspects to users in the rave setting; some users enjoy the feeling of mass communion from the inhibition-reducing effects of the drug, while others use it as party fuel because of the drug's stimulatory effects. MDMA is used less than other stimulants less than once per week. MDMA is sometimes taken in conjunction with other psychoactive drugs such as LSD, psilocybin mushrooms, ketamine, an act called "candy-flipping"; as of 2017, MDMA has no accepted medical indications. Before it was banned, it saw limited use in psychotherapy. A few psychotherapists continue to use MDMA in therapy despite the drug's legal status. Small doses of MDMA are used by some religious practitioners as an entheogen to enhance prayer or meditation. MDMA has been used as an adjunct to New Age spiritual practices. MDMA has become known as ecstasy referring to its tablet form, although this term may include the presence of possible adulterants or diluents.

The UK term "mandy" and the US term "molly" colloquially refer to MDMA in a crystalline powder form, thought to be free of adulterants. MDMA is sold in the form of the hydrochloride salt, either as loose crystals or in gelcaps. Due to the global supply shortage of sassafras oil—a problem assuaged by use of improved or alternative modern methods of synthesis—the purity of substances sold as molly have been found to vary widely; some of these substances contain methylone, ethylone, MDPV, mephedrone, or any other of the group of compounds known as bath salts, in addition to, or in place of, MDMA. Powdered MDMA ranges from pure MDMA to crushed tablets with 30–40% purity. MDMA tablets have low purity due to bulking agents that are added to dilute the drug and increase profi

List of magazines in Ireland

Below is a list of magazines published in Ireland. Film Ireland Hot Press The Journal of Music - classical and new music State Bloomers - for emerging female artists based in Ireland. Ireland's Own Ireland's Eye Irish Countrysports and Country Life Magazine, Irish hunting, shooting and country lifestyle magazine Nós - Irish language youth and lifestyle magazine RTÉ Guide Saint Martin's Magazine Construct Ireland - bi-monthly sustainable building title An Cosantóir - official monthly magazine of the Irish Defence Forces Signal - magazine of the Representative Association of Commissioned Officers Auto Trader Ireland The Brandsma Review - conservative Roman Catholic magazine Business and Finance Business Plus forth - outspoken current affairs review Fortnight Magazine - Northern Irish political magazine History Ireland Humanism Ireland IRIS Magazine - Sinn Féin magazine The Irish Humanist Irish Political Review Look Left - broad left magazine published by the Workers' Party Magill - political and cultural review The Phoenix - satirical and investigative magazine Saoirse Irish Freedom - monthly magazine of Republican Sinn Féin Village - monthly political magazine Ireland's PC Live! - consumer technology and computing Gay Community News - Ireland's oldest gay magazine Innovation - monthly technology supplement to the Irish Times ComputerScope Garda Review Irish Medical Times The Irish Skipper Plan - independent monthly architecture title Galway Now Ulster Tatler Category:Defunct magazines of Ireland Dawn and Dawn Train - Irish pacifist magazines, linked with the International Fellowship of Reconciliation Dublin Opinion Gralton magazine - leftist magazine Red Patriot and Voice of Revolution - Maoist, anti-clerical, pro-Irish republicanism magazines published by the Communist Party of Ireland The Ripening of Time - Marxist magazine

Create Project

The Create Project is a web-based community focused on communication and sharing between Free and Open Source Creative applications. The project was created by freedesktop.org as a space for collaboration between free software creative projects, since the project has become a full sub-project. Create now aims to consolidate shared resources for creative applications. Several community-developed specifications have begun to be developed under the project such as OpenRaster and the Swatches colour file format; some of the many groups that come together under this project include Blender, GIMP, Scribus, Open Clip Art Library, Open Font Library and the Aiki Framework which produce creative content, one of the major ways these groups come together is through the Libre Graphics Meeting, hosted by the Create Project. Libre Graphics Meeting FreeDesktop.org Inkscape GIMP Scribus sK1 Blender Audacity Open Clip Art Library Open Font Library Aiki Framework free and open-source software Open Source Developers' Conference Create Project official website at the Wayback Machine Create Project mailing list archives freedesktop.org