MSC Opera is a cruise ship built in 2004, carrying 2,679 passengers in 1,071 cabins, and with a crew complement of approximately 728, currently operated by Swiss company MSC Cruises. She served as the flagship of the company until MSC Musica entered service in 2006.

MSC Cruises is a Swiss-Italian global cruise line based in Geneva, with operations offices in Naples, Genoa and Venice. It was founded in 1970 in Naples, Italy, as part of the Mediterranean Shipping Company (MSC). In addition to being the world's largest privately held cruise company, employing about 23,500 people worldwide and with offices in 45 countries as of 2017, MSC Cruises is the third-largest cruise company in the world, after Carnival Corporation & plc and Royal Caribbean Group, with a 10.2% share of all passengers carried in 2021.