The MTV Video Music Brazil awards, more commonly known as VMB, were MTV Brasil's annual award ceremony, established in 1995. MTV viewers picked the winners for most categories since 2001.

The 2010 MTV Video Music Brazil, known as VMB 2010 in Brazil, was held on September 16, 2010, hosted by Marcelo Adnet and took place at the Credicard Hall, São Paulo. It awarded the best in Brazilian music, popular culture and internet culture in the year of 2010. The most notable moments in the show were the 5 awards received by pop band Restart, including for Best New Act and Act of the Year, this last sounded by boos from the audience. There was also a live performance by American alternative rock band OK Go, the appearance of electropop duo 3OH!3, Mexican singer Christian Chávez and Paraguayan model Larissa Riquelme, among many Brazilian personalities.