The MV Agusta 350 Ipotesi (Hypothesis) was a motorcycle produced by the Italian manufacturer MV Agusta from 1975 to 1977. The machine was conceived by Italian designer Giorgetto Giugiaro and based on the previous 350 B Sport Elettronica model. 1,991 "Sports" and 350 “Turismo” machines were produced.

MV Agusta is a high end motorcycle manufacturer founded by Count Domenico Agusta on 19 January 1945 as one of the branches of the Agusta aircraft company near Milan in Cascina Costa, Italy. The abbreviation MV stands for Meccanica (mechanics) Verghera, the hamlet where the first MVs were made. The modern headquarters and main production facilities are located in Varese, Italy on the shore of Lake Varese.