The MV Agusta 500 four-cylinder (1973–1976) was a racing motorcycle manufactured by the Italian company MV Agusta, for competing in the 500 cc series, the premier class of the FIM World Motorcycle Championship. With this motorcycle MV Agusta won the 1973 constructor's world champion and Phil Read won the 1973 and 1974 500 cc riders world championships.

MV Agusta is a high end motorcycle manufacturer founded by Count Domenico Agusta on 19 January 1945 as one of the branches of the Agusta aircraft company near Milan in Cascina Costa, Italy. The abbreviation MV stands for Meccanica (mechanics) Verghera, the hamlet where the first MVs were made. The modern headquarters and main production facilities are located in Varese, Italy on the shore of Lake Varese.