M/V Mississippi is a United States Army Corps of Engineers (USACE) towboat operating on the Mississippi River. It is the largest diesel towboat on the river.

The United States Army Corps of Engineers Mississippi Valley Division (MVD) is responsible for the Corps water resources programs within 370,000-square-miles of the Mississippi River Valley, as well as the watershed portions of the Red River of the North that are within the United States. It encompasses the entire Mississippi River from Lake Itasca, Minnesota, to the Gulf of Mexico. It excludes the watersheds of the Missouri River and Ohio River, and portions of the Arkansas River and the Red River of the South. The division includes all or parts of 13 states: Arkansas, Illinois, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Mississippi, Missouri, North Dakota, Tennessee, Wisconsin, and South Dakota.