The MacDonald House bombing was a sabotage attack on the MacDonald House building in Orchard Road, Singapore, on 10 March 1965, just a few months before Singapore's expulsion from Malaysia. The nitroglycerin bomb was planted by Indonesian saboteurs during the period of heightened Indonesia–Malaysia confrontation, also known as the Konfrontasi. The explosion killed three people and injured at least 33 others. At the time, the building was used by HSBC.

Orchard Road, often known colloquially as simply Orchard, is a major 2.5 km (1.6 mi)-long road in the Central Area of Singapore. A famous tourist attraction, it is an upscale shopping area, with numerous internationally renowned department stores, shopping malls, restaurants, and coffeehouses located in its vicinity. It's a popular hotspot in Singapore, especially at night, attracting trendy urban youth.