MacDonald "Mac" Gargan is a supervillain appearing in American comic books published by Marvel Comics. Created by writer Stan Lee and artist Steve Ditko, the character first appeared in The Amazing Spider-Man #19. Mac Gargan is a recurring antagonist of the superhero Peter Parker / Spider-Man. He debuted as a private investigator hired by J. Jonah Jameson to learn how Peter Parker took pictures of Spider-Man. In the following issue, Jameson decided to turn Gargan into a deadly adversary for Spider-Man through a barely-tested procedure, which left Gargan with an irremovable scorpion-themed armor and the predatory instincts of the arachnid. Driven insane by his mutation, Gargan instead turned to a life of crime as the Scorpion, and went on to menace both Spider-Man and Jameson, whom he held responsible for his transformation. Since then, having finally removed the armor, Gargan has also served as the third host of the Venom symbiote, and a member of the Dark Avengers as Spider-Man, but eventually returned to his Scorpion alias as it kept him alive due to the strain both the neural-armors and symbiote put on his body.

The Amazing Spider-Man is an ongoing American superhero comic book series featuring the Marvel Comics superhero Spider-Man as its title character and main protagonist. Being in the mainstream continuity of the franchise, it was the character's first title, launching seven months after his introduction in the final issue of Amazing Fantasy. The series began publication with a March 1963 cover date and has been published nearly continuously to date over six volumes with only one significant interruption. Issues of the title currently feature an issue number within its sixth volume, as well as a "legacy" number reflecting the issue's overall number across all Amazing Spider-Man volumes. The title reached 900 issues in 2022.