Macarthur railway station is located on the Main Southern line, serving the Sydney suburb of Campbelltown. It is served by Sydney Trains T8 Airport & South and NSW TrainLink Southern Highlands Line services. It is the southern extremity of the electrified Sydney Trains network.

The Main Southern Railway is a major railway in New South Wales, Australia. It runs from Sydney to Albury, near the Victorian border. The line passes through the Southern Highlands, Southern Tablelands, South West Slopes and Riverina regions.