Macon is a city in Noxubee County, Mississippi along the Noxubee River. The population was 2,768 at the 2010 census. It is the county seat of Noxubee County.

Edward Harrington, better known by his stage name Eddy Clearwater, was an American blues musician who specialized in Chicago blues. Blues Revue said he plays "joyous rave-ups…he testifies with stunning soul fervor and powerful guitar. One of the blues' finest songwriters."