Macon County is a county located in the northern portion of the U.S. state of Missouri. As of the 2020 census, the population was 15,209. Its county seat is Macon. The county was organized January 6, 1837, and named for Nathaniel Macon, a Revolutionary War hero and North Carolina politician.

Macon is a city in and the county seat of Macon County, Missouri, United States. The population was 5,457 at the 2020 census.