Macquarie Harbour is a shallow fjord in the West Coast region of Tasmania, Australia. It is approximately 315 square kilometres (122 sq mi), and has an average depth of 15 metres (49 ft), with deeper places up to 50 metres (160 ft). It is navigable by shallow-draft vessels. The main channel is kept clear by the presence of a rock wall on the outside of the channel's curve. This man-made wall prevents erosion and keeps the channel deep and narrow, rather than allowing the channel to become wide and shallow. A reported Aboriginal name for the harbour is Parralaongatek.

The West Coast of Tasmania is one of the regions of Tasmania in Australia. It is mainly isolated rough country and is associated with wilderness, mining and tourism. It served as the location of an early convict settlement in the early history of Van Diemen's Land, and contrasts sharply with the more developed and populous northern and eastern parts of the island state.