Madhouse is a 1990 American black comedy film starring Kirstie Alley and John Larroquette. Written and directed by Tom Ropelewski, it was produced by Leslie Dixon and released by Orion Pictures.

Kirstie Louise Alley was an American actress. Her breakthrough role was as Rebecca Howe in the NBC sitcom Cheers (1987–1993), for which she received an Emmy Award and a Golden Globe in 1991. From 1997 to 2000, she starred as the lead in the sitcom Veronica's Closet, earning additional Emmy and Golden Globe nominations. On film, she played Mollie Jensen in Look Who's Talking (1989) and its two sequels, Look Who's Talking Too (1990) and Look Who's Talking Now (1993).