The Madikwe Game Reserve is a protected area in South Africa. Named after the Madikwe or Marico River, on whose basin it is located. It comprises 750 km2 of bushland north of the small town of Groot-Marico up to the Botswana border. It was opened in 1994.

The Marico River or Madikwe is a river in Southern Africa. There are a number of dams in its basin. Groot Marico town is named after the Marico River. After it is joined on its right bank by the Crocodile River it is known as the Limpopo River.