Madison County is a county located in the western part of the U.S. state of Tennessee. As of the 2020 census, the population was 98,823. Its county seat is Jackson. Madison County is included in the Jackson, TN Metropolitan Statistical Area.

Jackson is a city in and the county seat of Madison County, Tennessee, United States. Located 70 miles (110 km) east of Memphis, it is a regional center of trade for West Tennessee. Its total population was 68,205 as of the 2020 United States census. Jackson is the primary city of the Jackson, Tennessee metropolitan area, which is included in the Jackson-Humboldt, Tennessee combined statistical area. Jackson is Madison County's largest city, and the second-largest city in West Tennessee after Memphis. It is home to the Tennessee Supreme Court's courthouse for West Tennessee, as Jackson was the major city in the west when the court was established in 1834.