Madisonville is the county seat of Monroe County, Tennessee, United States. It is located in East Tennessee on the eastern border of the state. As of the 2020 census, the city's population was 5,132.

Monroe County is a county located on the eastern border of the U.S. state of Tennessee. As of the 2020 census, the population was 46,250. Its county seat is Madisonville, and its largest city is Sweetwater.