Madonna di Pietraquaria is one of the titles by which the Holy Virgin Mary is venerated as the Patroness of the city of Avezzano, in Abruzzo, Italy. On 1 January 1978, Maria Santissima di Pietraquaria was proclaimed the patroness saint of the city of Avezzano. The Virgin Mary is celebrated with events and religious rites between 25 and 27 April.

Avezzano is a city and comune with a population of 40,864 inhabitants, situated in the Abruzzo region, province of L'Aquila, Italy. It is the second most populous municipality in the province and the sixth in the region. Avezzano was documented as an existing urban center in the ninth century. The city was destroyed by the earthquake of 1915. It was rebuilt after the 1944 Allied bombing. The city was decorated with the silver medal for civil merit, an award granted by the Italian Republic.