The Sanctuary of the Madonna of San Luca is a basilica church in Bologna, northern Italy, sited atop a forested hill, Colle or Monte della Guardia, some 300 metres above the city plain, just south-west of the historical centre of the city.

Bologna is the capital and largest city of the Emilia-Romagna region in Northern Italy. It is the seventh most populous city in Italy, with about 400,000 inhabitants and 150 different nationalities. Its metropolitan area is home to more than 1,000,000 people. It is known as the Fat City for its rich cuisine, and the Red City for its red tiled rooftops and, more recently, its leftist politics. It is also called the Learned City because it is home to the oldest university in the world.