The Madrean Region is a floristic region within the Holarctic Kingdom in North America, as delineated by Armen Takhtajan and Robert F. Thorne. It occupies arid or semiarid areas in the southwestern United States and northwestern Mexico and is bordered by the Rocky Mountain Floristic Region and North American Atlantic Region of the Holarctic Kingdom in the north and in the east, Caribbean Region of the Neotropical Kingdom in the south.

The Sonoran Desert is a hot desert in North America and ecoregion that covers the northwestern Mexican states of Sonora, Baja California, and Baja California Sur, as well as part of the southwestern United States. It is the hottest desert in both Mexico and the United States. It has an area of 260,000 square kilometers (100,000 sq mi).