Ramon Magsaysay Boulevard, also known simply as Magsaysay Boulevard and formerly as Santa Mesa Boulevard, is the principal artery of Santa Mesa in Manila, Philippines. It is a six-lane divided roadway that travels east–west from Gregorio Araneta Avenue near the city's border with Quezon City and San Juan to Lacson Avenue and the Nagtahan Interchange, close to the district of San Miguel. The entire length of the boulevard serves as the district boundary between Sampaloc in the north and Santa Mesa in the south with the LRTA's Line 2 running along its median. East of Gregorio Araneta, the road continues as Aurora Boulevard while west of Lacson, it extends as Legarda Street via Legarda Flyover into San Miguel and Quiapo.

National Route 180 (N180) is a secondary national route that forms part of the Philippine highway network, running from Cubao, Quezon City to Ermita, Manila.