Mahoning Creek is a tributary of the Susquehanna River in Columbia County and Montour County, in Pennsylvania, in the United States. It is approximately 10.6 miles (17.1 km) long and flows through Madison Township in Columbia County and West Hemlock Township, Derry Township, Valley Township, Mahoning Township, and Danville in Montour County. The watershed of the creek has an area of 39.6 square miles (103 km2). Its tributaries include Kase Run, Mauses Creek, and Sechler Run. Mahoning Creek is designated as a Trout-Stocking Fishery and a Migratory Fishery for part of its length and as a Warmwater Fishery and a Migratory Fishery for the remainder.

Montour County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 18,136. Its county seat is Danville. The county is named for Andrew Montour, a prominent Métis interpreter who served with George Washington during the French and Indian War. It encompasses 132 sq mi, making it the smallest county by land area in the state. The county is part of the Central Pennsylvania region of the state.