Makati Science High School is a public science high school in Taguig, Philippines. It is one of three science high schools of the City of Taguig, and it is managed by the Schools Divisions Office of Taguig City and Pateros (SDO-TAPAT). The City of Makati claims ownership and management of the school since it is located in a formerly disputed territory.

Taguig, officially the City of Taguig, is a coastal metropolis located in eastern shores of Metro Manila. It is the fifth-most populous city in the Philippines with a population of 1.2 million people. The city is one of the Philippines' cultural, financial, high-tech, entertainment and media centers with significant influence on commerce, health care, research, technology, education, politics, tourism, dining, art, fashion, and sports. Taguig is also an important center for the country's international diplomacy, hosting several embassies. The city also home to the headquarters of several major multinational corporations. Taguig has the fourth largest skyline in the Philippines, with 289 high-rises, 80 of which exceed 100 m (328 ft).