Malheur County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 31,571. Its county seat is Vale, and its largest city is Ontario. The county was named after the Malheur River, which runs through the county. The word "malheur" is French for misfortune or tragedy. Malheur County is included in the Ontario, Oregon Micropolitan Statistical Area, which is also included in the Boise Combined Statistical Area. It is included in the eight-county definition of Eastern Oregon.

Vale is a city in and the county seat of Malheur County, Oregon, United States, about 12 miles (19 km) west of the Idaho border. It is at the intersection of U.S. Routes 20 and 26, on the Malheur River at its confluence with Bully Creek.