Mameluke was a British Thoroughbred racehorse and sire. In a career that lasted from April 1827 to October 1829 he ran thirteen times and won seven races. Unraced as a two-year-old, he proved himself to be one of the best colts of his generation in 1827 when he won The Derby and finished second in the St Leger. Both races were surrounded by allegations of race-fixing and corruption. Mameluke raced with some success at four and five before retiring to stud. He was not a great success as a stallion.

The Derby Stakes, also known as the Derby or the Epsom Derby, is a Group 1 flat horse race in England open to three-year-old colts and fillies. It is run at Epsom Downs Racecourse in Surrey on the first Saturday of June each year, over a distance of one mile, four furlongs and 10 yards, or about 1½ miles. It was first run in 1780.