Mamikonian, or Mamikonean, was an aristocratic dynasty which dominated Armenian politics between the 4th and 8th centuries. They were the most notable noble house in Early Christian Armenia after the ruling Arsacid dynasty and held the hereditary positions of sparapet and dayeak, allowing them to play the role of kingmaker for the later Armenian kings. They ruled over extensive territories, including the Armenian regions of Tayk, Taron, Sasun, and Bagrevand, among others. The Mamikonians had a reputation as supporters of the Roman Empire in Armenia against Sasanian Iran, although they also served as viceroys under Persian rule. Their influence over Armenian affairs began to decline at the end of the 6th century and suffered a final, decisive blow after a failed rebellion against Arab rule over Armenia in 774/75.

Mushegh I Mamikonian was an Armenian military officer from the Mamikonian family who occupied the hereditary office of sparapet (generalissimo) of the Kingdom of Armenia under the Arsacid kings Pap and Varazdat. He took part in the Armenian resistance against the forces of the Sasanian monarch Shapur II, notably taking part in the Battle of Bagavan, where the Iranian forces were defeated. He was the regent of Armenia under the young and inexperienced Varazdat, who eventually suspected him of posing a danger to his rule, and thus had him executed, in 377/8.