Mamo Tower, also known as San Tommaso Tower, is a fortified residence in Marsaskala, Malta. It was built by the Mamo family in 1657 on rising ground above St Thomas Bay on the east shore of Malta.

Marsaskala, also written as Marsascala and abbreviated as M'Skala, is a seaside town in the South Eastern Region of Malta which has grown around the small harbour at the head of Marsaskala Bay, a long, narrow inlet also known as Marsaskala Creek. The bay is sheltered to the north by Ras iż-Żonqor, the southeast corner of Malta, and to the south by the headland of Ras il-Gżira. The parish church, built in 1953, is dedicated to Saint Anne and the feast is celebrated at the end of July in Marsaskala.