Mamoudzou is the capital city of Mayotte, a French overseas region and department in the Indian Ocean. Mamoudzou is the most populated commune (municipality) of Mayotte. It is located on Grande-Terre, the main island of Mayotte.

Mayotte, officially the Department of Mayotte, is an overseas department and region and single territorial collectivity of France. It is located in the northern part of the Mozambique Channel in the Indian Ocean off the coast of Southeastern Africa, between Northwestern Madagascar and Northeastern Mozambique. Mayotte consists of a main island, Grande-Terre, a smaller island, Petite-Terre, as well as several islets around these two. Mayotte is the most prosperous territory in the Mozambique Channel, making it a major destination for immigration.