Manatee County is a county in the U.S. state of Florida. As of the 2020 US Census, the population was 399,710. Manatee County is part of the North Port-Bradenton-Sarasota, Florida Metropolitan Statistical Area. Its county seat and largest city is Bradenton. The county was created in 1855 and named for the Florida manatee, Florida's official marine mammal. Features of Manatee County include access to the southern part of the Tampa Bay estuary, the Sunshine Skyway Bridge, and the Manatee River.

DeSoto County is a county located in the Florida Heartland region of the U.S. state of Florida. As of the 2020 census, the population was 33,976. Its county seat is Arcadia.