Manchester is a town in Meriwether and Talbot counties in the U.S. state of Georgia, although primarily in Meriwether. The population was 3,584 at the 2020 census, down from 4,230 in 2010. It is the most populous community in Meriwether County. CSX Transportation runs a railroad yard in Manchester.

Meriwether County is a county located in the west central portion of the U.S. state of Georgia. As of the 2020 census, the population was 20,613. The county seat is Greenville, home of the Meriwether County Courthouse. The county was formed on December 14, 1827, as the 73rd county in Georgia. It was named for David Meriwether, a general in the American Revolutionary War and member of Congress from Georgia.