The Manchester–Southport line is a railway line in the north-west of England, operated by Northern Trains. It was originally built as the Manchester and Southport Railway. The section between Wigan and Salford is also known locally as the Atherton Line.

The Northern line is one of two commuter rail routes operated by Merseyrail and centred on Merseyside, England, the other being the Wirral line. The cross-city route runs from Hunts Cross in south Liverpool then branches in the north to terminate at Southport, Headbolt Lane and Ormskirk (Lancashire).