The Manchester Evening News is a regional daily newspaper covering Greater Manchester in North West England. Founded in 1868, the paper is published Monday–Saturday; the newspaper is owned by Reach one of Britain's largest newspaper publishing groups. Since adopting a'digital-first' strategy in 2014, the publication has experienced huge online growth, while its average print daily circulation for the first half of 2018 was 36,715. In the 2018 British Regional Press Awards, it was named Newspaper of the Year and Website of the Year; the Manchester Evening News was first published on 10 October 1868 by Mitchell Henry as part of his Parliamentary election campaign, with its first issue four pages long and costing a halfpenny. The newspaper was run from a small office on Brown Street, with a dozen staff. Upon the newspaper's launch, Henry said: "In putting ourselves into print, we have no apology to offer, but the assurance of an honest aim to serve the public interest." Henry's quote is displayed on the entrance wall to the newspaper's modern offices.
With his Parliamentary bid unsuccessful, Henry lost interest in the business, selling the publication to John Edward Taylor Jr. the son of newspaper proprietor John Edward Taylor, founder of the Manchester Guardian. The newspaper became the evening counterpart and sister title to The Manchester Guardian and the two titles began sharing an office, located on Cross Street, from 1879. Taylor brought his brother-in-law Peter Allen in as a partner in the Manchester Evening News and, after Taylor's death in 1907, the Guardian was sold to its editor C. P. Scott while the Evening News passed into the hands of the Allen family. In 1924, C. P. Scott's son John Russell Scott reunited the papers, buying out the Manchester Evening News and forming The Manchester Guardian and Evening News Ltd, which in turn became the Guardian Media Group. In 1936, John Russell Scott formed the Scott Trust in order to protect the company from death duties, following the deaths of his father and younger brother Ted in close succession.
The contents of the original deeds were not disclosed by the company, but a copy obtained by The Independent revealed the terms compelled trustees to "use their best endeavours to procure that the Manchester Guardian and Manchester Evening News shall be carried on as nearly as may be upon the same principles as they have heretofore."During the editorship of William Haley in the 1930s, the newspaper's circulation grew to over 200,000. By 1939 the publication was the largest provincial evening newspaper in the country; the newspaper was a cash cow for its parent company and kept its stablemate The Manchester Guardian afloat. The financial success of the Manchester Evening News was reflected in Haley's salary, greater than John Scott's, with Scott himself acknowledging, "after all, you make the money we spend."In 1961, The Manchester Guardian and Evening News Ltd bought out the Manchester Evening News's ailing rival, the Manchester Evening Chronicle, two years merged the papers. Following this, the Manchester Evening News's circulation increased to over 480,000.
In December 2009, GMG confirmed it had held "exploratory talks" about selling the Manchester Evening News, following a report by The Daily Telegraph which named Trinity Mirror as a potential buyer and claimed the "disposal would amount to a fire sale" due to the current value of the business. The title estimated the Manchester Evening News alone to be worth about £200m prior to the collapse in newspaper advertising. In February 2010, the Manchester Evening News was sold along with GMG's 31 other regional titles to Trinity Mirror, severing the historic link between The Guardian and the Manchester Evening News; the sale was valued at £44.8m – £7.4m in cash and the remainder from GMG extricating itself from a £37.4m decade-long contract with Trinity Mirror to print its regional titles. The sale of GMG's regional arm was negotiated to offset company losses, with The Guardian and its Sunday title Observer accruing losses of £100,000 a day; the sale was described by stockbrokers Numis as "the deal of the decade" for Sly Bailey, Trinity Mirror's chief executive, while The Guardian's Steve Busfield said the sale was indicative of the declining business value of regional media, comparing the sale to that of Johnston Press's acquisition of 53 regional titles including The Yorkshire Post eight years earlier, for £560m.
In the year prior to the newspaper's sale, GMG had reduced the number of journalists at the newspaper to 50. Judy Gordon, the National Union of Journalists mother of the chapel, said: "The Guardian has not got any money of its own, it has only got. We've made all those changes to stem the fact, they ask:'How much can you give us now? Nothing? OK, Bye.'"The Manchester Evening News headquarters were relocated from Scott Place in the Spinningfields area of Manchester city centre to an existing Trinity Mirror plant in Chadderton, where other Trinity Mirror titles in North West England are printed. In 2013, the title surpassed 10 million monthly online readers for the first time, recording 10,613,119 visitors. Despite its "evening" title, the newspaper began publication of a morning edition in November 2004, a controversial move which brought union members to the brink of strike action over new work rotas. For years the paper was famous for its "Football Green" edition. After the MEN merged with the rival Manchester Evening Chronicle in the 1960s, its more popular "Sporting Pink" was adopted as the "Football Pink".
Araku railway station is an Indian railways station located near Araku Valley of Visakhapatnam district in the state of Andhra Pradesh. It belongs to south Coast Railway zone under Waltair railway division; the railway station is situated at about 935 meters elevation. In 1960, Indian Railway took up three projects: the Kothavalasa – Araku – Koraput – Jeypore – Jagdalpur – Dantewara – Kirandaul line, the Jharsuguda – Sambalpur – Bargarh – Balangir – Titlagarh Project and the Biramitrapur – Rourkela – Bimlagarh – Kiriburu project. All the three projects taken together were popularly known as the DBK Project or the Dandakaranya – Bolangir – Kiriburu project; the Kothavalasa–Kirandul line was opened in 1966–67 under South Eastern Railway Zone with financial aid of Japan for transporting Iron ore. Electrification of the Araku railway station was completed in 1982 Borra Caves Visakhapatnam - Araku AC Tourist Passenger Araku Valley Araku railway station at the India Rail Info
Gwendolyn Wright is an award-winning architectural historian, co-host of the PBS television series History Detectives. She is a professor of architecture at Columbia University holding appointments in both its departments of history and art history. Besides "History Detectives", Dr. Wright's specialties are US architectural history and urban history from after the Civil War to the present, she writes about the exchange across national boundaries of architectural styles and techniques examining the colonial and neo-colonial attributes of both modernism and historic preservation. Gwendolyn Wright attended New York University, in 1969 received a BA in history and art history, she did her graduate work at the University of California and was awarded her M. Arch in 1974 and her PhD in Architecture in 1978, she published her first book in 1980. Wright was hired by Columbia University in 1983, two years becoming the first female to gain tenure in its prestigious Graduate School of Architecture and Preservation.
She succeeded founder Robert A. M. Stern as director of the Buell Center for the Study of American Architecture, serving in that capacity from 1988 to 1992. In 2002, she was hired by television producers to be part of what would become the new TV series "History Detectives". Back the working title for the show was “American Attic”, the initial concept was to tell stories of history through a focus on houses, hence their interest in adding an experienced architectural historian like Wright; the concept has evolved into solving historical puzzles that use a wide variety of tangible objects to show how historians piece together various kinds of knowledge—and conflicting evidence and diverse perspectives—about what happened and why. The show has become one of the most popular and successful programs on PBS. Wright has remained one of the five hosts in front of the camera from its initial broadcast season in 2003 to the present. In the show's publicity, she is held up as the team member most to suggest how to proceed when the rest are stymied.
She has authored four books, edited two others, written numerous articles and essays. Gwendolyn Wright has been recognized for her achievements on numerous occasions, including a John Simon Guggenheim Memorial Foundation Fellowship, 2004-5, a Fellowship in the Humanities from the Ford Foundation, 1979–80, she was elected a fellow in the Society of American Historians in 1985, honoring literary quality in historical writing. Wright is married to the historian Anson Rabinbach, she has a daughter, Sophia Bender Koning, a stepson, David Bender. Moralism and the Model Home: Domestic Architecture and Cultural Conflict in Chicago, 1873-1913. 1980 University of Chicago Press. ISBN 978-0-226-90835-9 Chicago residential architectural history in the context of competing economic and cultural forces during the pivotal years 1873-1913. Building the Dream: A Social History of Housing in America. 1981. New York: Pantheon. ISBN 978-0-394-50371-4 US residential architectural history in the context of other developments since the late 1600s.
The History of History in American Schools of Architecture, 1865-1975. 1990. New York: Princeton Architectural Press. ISBN 978-1-878271-02-0 Examination of the role of and changes in the teaching of history within US schools of architecture, including the relationship of architectural history to architectural theory and learning; the Politics of Design in French Colonial Urbanism. 1991. University Of Chicago Press. ISBN 978-0-226-90848-9 Morocco and Madagascar architectural history during the French colonial administration; the Formation of National Collections of Art and Archaeology. 1995. CASVA/National Gallery of Art. ISBN 978-0-300-07718-6 Examination of the architecture and contents of museums and their role in depicting and shaping national identities and aspirations. USA: Modern Architectures in History. 2008. Reaktion Press/University of Chicago. ISBN 978-1-86189-344-4 US architectural history survey emphasizing Modernism as a response to changing economic and cultural conditions since 1865. Iva Toguri D'Aquino History of Alcoholics Anonymous Social situation in the French suburbs About Gwendolyn Wright, page on PBS "History Detectives" website PBS "History Detectives" Host/Historian Gwendolyn Wright, YouTube interview by Mark Molaro on The Alcove Gwendolyn Wright, Wright's own website
Bemidji Airlines is an American airline based in Bemidji, Minnesota USA. It operates domestic cargo flights, as well as extensive air taxi services, its main base is Bemidji Regional Airport, with a hub at Minneapolis-Saint Paul International Airport. The airline was established in 1946 and started operations in 1947 operating a single Noorduyn Norseman aircraft. After acquisition by a partnership in 1970 the company operated four Cessna 150 aircraft for fire patrol, flight instruction and passenger charter services. From 1981 to 1991, the airline operated with scheduled service from Bemidji. In the mid-eighties they expanded the business to include many regional cargo freight runs, added many larger aircraft. Since 1991, primary activities have been small-feeder cargo services and cargo charters, typical fixed-base operations at the Bemidji Airport. In January 2017, Sioux Falls, South Dakota based Business Aviation Courier was acquired from BBA Aviation. With the 2017 acquisition, the company now has 120 employees.
The company became a 100% ESOP in 2007. Bemidji Airlines operates domestic cargo/passenger services within Minnesota, Colorado, Nebraska and South Dakota as well as extensive charter and air taxi work within USA and Canada; the Bemidji Airlines fleet consists of the following aircraft: 10 Beechcraft 99, 99A or C99 15 Fairchild Metro III Model AC227-AC 20 Beechcraft Queenair with Excalibur Modification 1 Beechcraft King Air E90 1 Beechcraft 58 Baron 2 Cessna 404 Titan 5 Cessna 402B 3 Cessna 172 Bemidji Aviation Encore Air Cargo
John Reynald Marcelo Tiangco is a Filipino politician and the incumbent representative for the district of Navotas City. He served as Mayor of Navotas, succeeding his brother Toby Tiangco. John Rey Tiangco ran unopposed for mayor in the 2010 Navotas local elections for the local party, Partido Navoteño. At the same time, his brother, Tobias "Toby" Tiangco, who had founded the party and had just completed his third term as the mayor of Navotas, ran for a position in the House of Representatives. John Rey became mayor of Navotas on June 30, 2010. Under the slogan "Navotas, NavotaAs! Itaas ang antas ng buhay Navoteño", he vowed to prioritize health, livelihood and order, housing projects in Navotas City. In cooperation with his brother Tobias, Tiangco made rapid progress with government projects, they announced that the first public hospital in the city would be built, construction began in August 2014. Housing projects sought to provide relief to those displaced by fires or living in danger zones, additional pumping stations were established due to the city's flooding problems.
In education, Tiangco's administration launched the NavotaAs Scholarship Program, Kindergarten on Wheels, Computer Outreach Learning. Under his administration, CCTVs were installed for public security and additional emergency response vehicles entered service. Tiangco was elected to a second term in the 2013 Navotas local elections, with Partido Navoteño securing every seat in the Navotas City Council. Tiangco's biggest accomplishment during his second term as mayor was the opening of the Navotas City Hospital. Other projects included establishing Navotas Manpower Training Center and Tumana Public Market at Brgy. NBBS Dagat-dagatan, an additional health center at NBBS Kaunlaran. Tiangco ran unopposed in the 2016 elections. Under Tiangco's third administration, the city added a hemodialysis unit at Navotas City Hospital. New health facilities, housing projects and livelihood programs were established, he initiated drug-rehabilitation program Bidahan. The NavoBangka program provided free fishing boats to deserving fisherfolk, a scholarship was provided for the children of fisherfolk as well as athletic and art scholarships, cash incentives for public school graduates.
Other programs launched during his third term include the Navoteño Film Festival, Avot tour, One on One with Juan, NavoConnect Free Wifi, R10 Family Zone, free birth registration, a baby care kit for newborns. Tiangco ran for the congressional seat for Navotas City in the 2019 elections. For this election, Partido Navoteño entered into an alliance with Hugpong ng Pagbabago, the party of Sara Duterte-Carpio, he won, exchanged positions with his brother Toby, who had represented the city for the preceding nine years. John Rey received 80,265 votes compared to his closest opponent, Marielle del Rosario, who received 30,050 votes. Tiangco has been recognized with: Bronze Seal of Good Housekeeping Silver Seal of Good Housekeeping Seal of Good Local Governance Seal of Child-Friendly City Commission on Audit Unqualified Opinion NCR Top 1, 2017 BLGF Collection Target for Receipts from Economic Enterprises NCR Top 2, 2017 BLGF Collection Target for Total Local Revenues 2017 Timely and Accurate Submission of Electronic Statement of Receipts and Expenditures Galing Pook Award Seal of Good Education Governance National Anti-Drug Abuse Council Performance Award Most Outstanding Accounting Office Controversy arose in July 2011 when a private organization filed a case with the Ombudsman of the Philippines against many prominent figures in the Navotas government for violating Republic Act 3019.
The individuals involved include Tiangco, his brother Tobias, vice mayor P. J. Javier, every member of the city council, they were accused of approving a city resolution that would cause "automatic withdrawal of the recognition and acknowledgement" of the complainant, resulting in significant negative impacts. Tiangco has been criticized by the residents of Tangos, a barangay of Navotas. Locals claimed that he disregarded complaints about muddy roads and otherwise paid no attention to the situation within Tangos; the residents' representative said that "even there are no floods around our barangay, problem: the large amount of mud on roads". The source of this mud has been attributed to city drainage improvement projects that have involved large amounts of excavation; those whose children attend Tangos Elementary School or Navotas High School say that the students are forced to walk long distances on muddy roads every day on their way to school and that the road, narrow when it was constructed, has been narrowed by mud coverage to become impassable to motor vehicles.
Inquiries were raised on why the repaving project on Epifanio Delos Santos Avenue was finished within one week, while their problem has remained unaddressed for months
TCAIM is a protein that in humans is encoded by the TCAIM gene. The gene is located on chromosome 3, at position 3p21.31, is 71,333 bases long. A graphic of the image is show below in Fig.1.2 The TCAIM protein is 496 residues long and weighs 57925 Da. It exists in four different isoforms. TCAIM is conserved among different species, but no homologies to protein families of known functions were discovered. There are 8 alternatively spliced exons; the primary transcript, 3520 bp, is well conserved among orthologs, with the human isoform 1 having high identity with orthologous proteins. The X1 transcript contains 11 exons, which yield a polypeptide, 496 amino acid residues in length; the isoelectric point is greater than average for human proteins. Shown to the right is a predicted tertiary structure of the protein, it is composed of long alpha-helices with several coil regions and strands dispersed throughout the length of the protein. The ends of the protein consist of coil regions opposite the N- and C- terminal ends.
TCAIM is moderately expressed in most tissues in the body. However, a study on NCBI GEO discussing the effect of disease states on TCAIM mRNA expression found that protein expression was elevated in HPV positive tissues compared to the HPV negative tissues. Another study found that TCAIM expression was elevated in individuals with Type 2 diabetes and insulin resistance; the expression of TCAIM seems to be contingent on the specific disease state in a variety of cases. The protein contains a mitochondrial signal peptide localizing it to the mitochondrial matrix. Analysis via the EXPASY localization software confirmed this finding; the high isoelectric point of the Human protein provides further evidence for the mitochondrial localization due to the high pH of the mitochondrial matrix. The protein is cleaved to remove the 26 amino acids from the N-terminus; this represents. There are a number of predicted phosphorylation sites. Serine residues are more to undergo phosphorylation than threonine or tyrosine residues.
Shown to the right are a number of predicted o-linked sites. None have been experimentally determined thus far. An alignment of Homo sapiens TCAIM and Danio rerio homologs was performed using the SDSC workbench. There is 55% identity between the two orthologs, with a global alignment score of 1817; the two orthologs are similar throughout the entirety of their sequences. The differences between the two genes is due random segments of non-conserved and semiconserved residues scattered throughout the two alignments; this difference may be due to the non-relatedness between the two organisms. TCAIM diverged much quicker than cytochrome C, but slower than fibrinogen. Not much is known about the function. TCAIM may play a role in the innate immune signaling via the mitochondria. A research study was performed by al.. They found that TCAIM is expressed in grafts and tissues of tolerance-developing transplant patients and that the protein is localized in the mitochondria. In this study, they found that TCAIM is regulated by CD11c dendritic cells.
Another article by Hendrikson et. el mentions TCAIM. They found; the third article is another research that finds evidence that TCAIM could be used as a marker in patients to predict whether they could accept an allograft or reject it. Human TCAIM genome location and TCAIM gene details page in the UCSC Genome Browser