Manchester Piccadilly is the main railway station of the city of Manchester, in the metropolitan county of Greater Manchester, England. Opened originally as Store Street in 1842, it was renamed Manchester London Road in 1847 and became Manchester Piccadilly in 1960. Located to the south-east of the city centre, it hosts long-distance intercity and cross-country services to national destinations including London, Birmingham, Nottingham, Glasgow, Edinburgh, Cardiff, Bristol, Exeter, Plymouth, Reading, Southampton and Bournemouth; regional services to destinations in Northern England including Liverpool, Leeds, Sheffield, Newcastle and York; and local commuter services around Greater Manchester. It is one of 19 major stations managed by Network Rail. The station has 14 platforms: 12 terminal and two through platforms. Piccadilly is also a major interchange with the Metrolink light rail system with two tram platforms in its undercroft.

Bristol Temple Meads is the oldest and largest railway station in Bristol, England. It is located 118 miles 31 chains away from London Paddington. It is an important transport hub for public transport in the city; there are bus services to many parts of the city and surrounding districts, with a ferry to the city centre. Bristol's other major station, Bristol Parkway, is a more recent station on the northern outskirts of the conurbation. It is the busiest station in South West England.