Manchester Piccadilly is the main railway station of the city of Manchester, in the metropolitan county of Greater Manchester, England. Opened originally as Store Street in 1842, it was renamed Manchester London Road in 1847 and became Manchester Piccadilly in 1960. Located to the south-east of the city centre, it hosts long-distance intercity and cross-country services to national destinations including London, Birmingham, Nottingham, Glasgow, Edinburgh, Cardiff, Bristol, Exeter, Plymouth, Reading, Southampton and Bournemouth; regional services to destinations in Northern England including Liverpool, Leeds, Sheffield, Newcastle and York; and local commuter services around Greater Manchester. It is one of 19 major stations managed by Network Rail. The station has 14 platforms: 12 terminal and two through platforms. Piccadilly is also a major interchange with the Metrolink light rail system with two tram platforms in its undercroft.

Manchester City Centre is the central business district of Manchester, England, within the confines of Great Ancoats Street, A6042 Trinity Way, and A57(M) Mancunian Way, which collectively form an inner ring road. The City Centre ward had a population of 17,861 at the 2011 census.