The Manchester Regiment was a line infantry regiment of the British Army in existence from 1881 until 1958. The regiment was created during the 1881 Childers Reforms by the amalgamation of the 63rd Regiment of Foot and the 96th Regiment of Foot as the 1st and 2nd battalions; the 6th Royal Lancashire Militia became the 3rd (Reserve) and 4th battalions and the Volunteer battalions became the 5th, 6th, 7th, 8th, 9th and 10th battalions.

The 6th Royal Lancashire Militia was an auxiliary regiment raised in the county of Lancashire in North West England just before the Crimean War. It later became part of the Manchester Regiment. Although primarily intended for home defence, its battalions saw active service during the Second Boer War. Following conversion to the Special Reserve (SR) under the Haldane Reforms it supplied reinforcements to the fighting battalions during World War I. After a shadowy postwar existence the unit was finally disbanded in 1953.