The Manchester Regiment was a line infantry regiment of the British Army in existence from 1881 until 1958. The regiment was created during the 1881 Childers Reforms by the amalgamation of the 63rd Regiment of Foot and the 96th Regiment of Foot as the 1st and 2nd battalions; the 6th Royal Lancashire Militia became the 3rd (Reserve) and 4th battalions and the Volunteer battalions became the 5th, 6th, 7th, 8th, 9th and 10th battalions.

The 63rd Regiment of Foot was a British Army regiment raised in 1756. Under the Childers Reforms, it amalgamated with the 96th Regiment of Foot to form the Manchester Regiment in 1881.