Manchester Royal Infirmary (MRI) is a large NHS teaching hospital in Chorlton-on-Medlock, Manchester, England. Founded by Charles White in 1752 as part of the voluntary hospital movement of the 18th century, it is now a major regional and national medical centre. It is the largest hospital within Manchester University NHS Foundation Trust, and based on its Oxford Road Campus in South Manchester where it shares a site with the Royal Manchester Children's Hospital, Manchester Royal Eye Hospital and Saint Mary's Hospital as well as several other educational and research facilities. The Hospital is also a key site for medical educational within Manchester, serving as a main teaching hospital for School of Medical Sciences, University of Manchester.

Chorlton-on-Medlock is an inner city area of Manchester, England.