Manhattan High School is a public high school in Manhattan, Kansas, United States, serving students in grades 9–12. It is part of the Manhattan–Ogden USD 383 school district. For the 2013–2014 school year, Manhattan High had an enrollment of 1,920 students.

Manhattan is a city in and the county seat of Riley County, Kansas, U.S., although the city extends into Pottawatomie County. It is located in northeastern Kansas at the junction of the Kansas River and Big Blue River. As of the 2020 Census, the population of the city was 54,100.