Manhattanville is a neighborhood in the New York City borough of Manhattan bordered on the north by 135th Street; on the south by 122nd and 125th Streets; on the west by Hudson River; and on the east by Adam Clayton Powell Jr. Boulevard and the campus of City College.

Manhattan College is a private, Catholic, liberal arts university in the Bronx, New York City. Originally established in 1853 by the Brothers of the Christian Schools as an academy for day students, it was later incorporated as an institution of higher education through a charter granted by the New York State Board of Regents. In 1922, it moved from Manhattan to the Riverdale section of the Bronx, roughly 6.4 miles (10.3 km) north of its original location on 131st Street in Manhattanville.