Manila is a city in Mississippi County, Arkansas, United States. The population was 3,682 at the 2020 census, up from 3,342 in 2010. It was the hometown of World War I sniper Herman Davis.

Mississippi County is the easternmost county in the U.S. state of Arkansas. As of the 2020 census, the population was 40,685. There are two county seats, Blytheville and Osceola. The county is named for the Mississippi River which borders the county to the east. Mississippi County is part of the First Congressional District in Arkansas.