Manitou Lake is a salt lake located mostly in the RM of Manitou Lake No. 422 in the Canadian province of Saskatchewan, about 10 kilometres (6.2 mi) east of the provincial border with Alberta. The eastern shore of the lake is in the RM of Hillsdale No. 440. Manitou Lake is located in a region called the Prairie Pothole Region of North America, which extends throughout three Canadian provinces and five U.S. states. It is also within Palliser's Triangle and the Great Plains ecoregion. Manitou Lake is part of an Important Bird Area (IBA) of Canada that covers 699.66 km2 (270.14 sq mi) of land and serval neighbouring lakes.

The Rural Municipality of Manitou Lake No. 442 is a rural municipality (RM) in the Canadian province of Saskatchewan within Census Division No. 13 and SARM Division No. 6.