Mannheim, officially the University City of Mannheim, is the second-largest city in the German state of Baden-Württemberg, after the state capital of Stuttgart, and Germany's 21st-largest city, with a 2021 population of 311,831 inhabitants. The city is the cultural and economic centre of the Rhine-Neckar Metropolitan Region, Germany's seventh-largest metropolitan region with nearly 2.4 million inhabitants and over 900,000 employees.

The Neckar is a 362-kilometre-long (225 mi) river in Germany, mainly flowing through the southwestern state of Baden-Württemberg, with a short section through Hesse. The Neckar is a major right tributary of the Rhine. Rising in the Schwarzwald-Baar-Kreis near Schwenningen in the Schwenninger Moos conservation area at a height of 706 m (2,316 ft) above sea level, it passes through Rottweil, Rottenburg am Neckar, Kilchberg, Tübingen, Wernau, Nürtingen, Plochingen, Esslingen, Stuttgart, Ludwigsburg, Marbach, Heilbronn and Heidelberg, before discharging on average 145 m3/s (5,100 cu ft/s) of water into the Rhine at Mannheim, at 95 m (312 ft) above sea level, making the Neckar its 4th largest tributary, and the 10th largest river in Germany. Since 1968, the Neckar has been navigable for cargo ships via 27 locks for about 200 kilometres (120 mi) upstream from Mannheim to the river port of Plochingen, at the confluence with the Fils.