Mannheim Hauptbahnhof is a railway station in Mannheim in the German state of Baden-Württemberg. It is the second largest traffic hub in southwestern Germany behind Stuttgart Hauptbahnhof, with 658 trains a day, including 238 long-distance trains. It is also a key station in the Rhine-Neckar S-Bahn. 100,000 passengers embark, disembark or transfer between trains at the station each day. The station was modernised in 2001. It is classified by Deutsche Bahn as a category 2 station.

Mannheim, officially the University City of Mannheim, is the second-largest city in the German state of Baden-Württemberg, after the state capital of Stuttgart, and Germany's 21st-largest city, with a 2021 population of 311,831 inhabitants. The city is the cultural and economic centre of the Rhine-Neckar Metropolitan Region, Germany's seventh-largest metropolitan region with nearly 2.4 million inhabitants and over 900,000 employees.