Mano Po Legacy: The Flower Sisters is a Philippine television drama series broadcast by GMA Network. The series is the third installment of Mano Po Legacy. Directed by Ian Loreños, it stars Aiko Melendez, Beauty Gonzalez, Thea Tolentino and Angel Guardian all in the title roles. It premiered on October 31, 2022 on the network's Telebabad line up replacing What We Could Be. The series concluded on January 13, 2023 with a total of 47 episodes. It was replaced by Luv Is in its timeslot.

Mary Aiko Shimoji Melendez, known professionally as Aiko Melendez, is a Filipino actress and politician. She currently serves as a councilor of Quezon City from the 5th district since 2022, a position she previously held from the 2nd District from 2001 to 2010. Her father, Jimmy Melendez, was an actor. Her half-brother, Jam Melendez, also entered showbusiness.