Manoel Island, formerly known as Bishop's Island or the Isolotto, is a small island which forms part of the municipality of Gżira in Marsamxett Harbour, Malta. It is named after the Portuguese Grand Master António Manoel de Vilhena, who built a fort on the island in the 1720s.

Gżira is a town in the Central Region of Malta. It is located between Msida and Sliema, also bordering on Ta' Xbiex. It has a population of 11,699 as of January 2019. The word Gżira means "island" in Maltese, and the town is named after Manoel Island which lies to the east of Gżira, between the Sliema peninsula and Valletta. The seafront of Gżira has views of the walled city of Valletta, which is illuminated at night, forming a backdrop to Manoel Island, the yacht marina and a seafront public garden. Kappara is located close to Gżira. The Orpheum Theatre is located in Gżira.