Manuel Komnenos Doukas, Latinized as Ducas, commonly simply Manuel Doukas and rarely also called Manuel Angelos, was ruler of Thessalonica from 1230 to 1237 and, after his expulsion from Thessalonica, of Thessaly from 1239 until his death in c. 1241.

The history of Thessaly covers the history of the region of Thessaly in north-central Greece from antiquity to the present day.