Manuel I, known as the Fortunate, was King of Portugal from 1495 to 1521. A member of the House of Aviz, Manuel was Duke of Beja and Viseu prior to succeeding his cousin, John II of Portugal, as monarch. Manuel ruled over a period of intensive expansion of the Portuguese Empire owing to the numerous Portuguese discoveries made during his reign. His sponsorship of Vasco da Gama led to the Portuguese discovery of the sea route to India in 1498, resulting in the creation of the Portuguese India Armadas, which guaranteed Portugal's monopoly on the spice trade. Manuel began the Portuguese colonization of the Americas and Portuguese India, and oversaw the establishment of a vast trade empire across Africa and Asia.

The Portuguese Empire, also known as the Portuguese Overseas or the Portuguese Colonial Empire, was composed of the overseas colonies, factories, and later overseas territories, governed by the Kingdom of Portugal. It was one of the longest-lived colonial empires in European history, lasting almost six centuries from the conquest of Ceuta in North Africa in 1415, to the transfer of sovereignty over Macau to China in 1999. The empire began in the 15th century, and from the early 16th century it stretched across the globe, with bases in Africa, North America, South America, and various regions of Asia and Oceania.